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You might ask what is the Talisman?
Well according to blizzard devs, its a feature in your character profile where you can customize your character. The purpose of the talisman is to alter attributes with gems and possible other modifiers.
It is a very interesting topic because lots of people complain about “automatic stats customization” – so maybe blizz have a great solution here. The feature didn’t work under the Diablo 3 BlizzCon demo.
Description of picture: In the middle of the character profile there is a circle (the Talisman) with 9 slots where you can put gems into it.
Please posts your comments if you know more about the Talisman 
[...] Fuente: Diablo3x [...]
[...] : here « Witch Doctor Gameplay [...]
Depending on the number of possible modifiers this might lead to a very unique character design! Related to D2 this makes 6 types of gems (including skulls) in 5 different stats. Combined with 9 slots this leads to hell a lot of combinations – not even thinking about rune-like combinations…
I wonder wheteher combinations and their results will be depending on luck or whether there is kind of a guideline to combine the modifiers.
Sounds great! Looking forward to hearing / reading more about this!